Hemoglobin structure and function
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The CYB5R3 T117S variant reduces riociguat efficacy by impairing nitric oxide signaling in sickle cell disease patients.
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The Band 3-BLVRB interaction acts as an oxygen-sensitive switch regulating red blood cell metabolism, with hypoxia causing dissociation and metabolic remodeling.
Genomic and proteomic profiling can transform blood transfusion into a predictive, biologically rich system, enabling personalized and resilient blood products.
HDP is essential for mitochondrial protein synthesis in Plasmodium, with knockout disrupting electron flow and causing developmental arrest, independent of hemozoin formation.
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Mitochondrial haem scarcity is detected by an ancient OMA1-DELE1 pathway that regulates translation during erythroid development, conserved across species including invertebrates.
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