Precision transfusion medicine in the omics era.

Genomic and proteomic profiling can transform blood transfusion into a predictive, biologically rich system, enabling personalized and resilient blood products.

• Why it matters: Current transfusion practices treat blood mainly as a commodity, missing opportunities to leverage molecular data for improved safety, efficacy, and donor-recipient matching, which is crucial for advancing personalized medicine.
• What they did: The authors propose integrating omics approaches, including genomics and repeated metabolomic profiling, into blood donation and transfusion workflows, creating a "blood unit+" enriched with biological context.
• The result: This approach could enable blood systems to serve as public health observatories, improve donor engagement, and optimize transfusion outcomes through molecular insights, artificial intelligence, and longitudinal data integration.