Primary cilia: sensors of biliary homeostasis and disease.

Primary cilia on cholangiocytes act as sensors that regulate biliary homeostasis and are linked to biliary ciliopathies with cystic lesions, fibrosis, and strictures.

• Why it matters: Understanding how primary cilia influence biliary function is crucial because alterations in their structure or function cause a broad spectrum of biliary diseases lacking targeted treatments, impacting patient outcomes.
• What they did: The authors review the structure and function of cholangiocyte primary cilia and summarize known biliary ciliopathies, highlighting their role in sensing bile composition and flow.
• The result: This overview underscores the potential for developing novel therapies targeting primary cilia, which may improve treatment options for biliary ciliopathies.