Transgenerational Effects of Paternal in Utero Arsenic Exposure on MASLD-like Phenotypes.

Paternal in utero arsenic exposure causes MASLD-like phenotypes in F1 and transmits core features to F2 offspring, with effects persisting mainly in males.

• Why it matters: Understanding how early-life environmental toxins affect subsequent generations is crucial for assessing long-term health risks and developing preventive strategies.
• What they did: The study involved exposing pregnant dams to arsenic, then evaluating metabolic and liver phenotypes in F1 and F2 offspring at specific postnatal weeks, focusing on hepatic steatosis, glucose intolerance, and insulin resistance.
• The result: Core MASLD-like features, including hepatic steatosis and glucose intolerance, were transmitted from F1 to F2, especially in males, while obesity and hormonal changes showed transgenerational attenuation, highlighting lasting but selective effects.