Distinct extracellular architectures shape mechanical persistence in GPVI and CLEC-2 receptor assemblies.

Receptor architecture determines mechanical persistence, with domain-swapped GPVI showing greater force resistance than reconstructed GPVI and CLEC-2 during separation.

• Why it matters: Understanding how extracellular receptor arrangements influence force transmission is crucial for insights into thrombus stability and receptor cluster longevity under mechanical stress.
• What they did: Molecular dynamics simulations compared the force response of GPVI and CLEC-2 receptor assemblies, focusing on separation forces and extension endpoints under constant-force conditions.
• The result: Domain-swapped GPVI maintained resistance over larger separation distances and exhibited significantly greater mechanical persistence than reconstructed GPVI, implying architecture impacts receptor stability under load.