5-oxoETE links redox control of epithelial damage detection and resilience.

5-oxoETE, regulated by NADP+/NADPH, links redox sensing to immune defense and tissue resilience in zebrafish and human cells.

• Why it matters: Understanding how tissues balance inflammation and repair during oxidative stress is crucial for developing therapies for tissue damage and inflammatory diseases.
• What they did: The study used live zebrafish and human cell models to investigate DHRS7's role in producing or consuming 5-oxoETE based on NADP+/NADPH levels, revealing its impact on immune signaling and epithelial protection.
• The result: Findings show 5-oxoETE activates immune cells at wounds and promotes epithelial cell survival by inducing NUDIX hydrolases, enabling tissues to respond adaptively to oxidative stress.