Regulatory T cells in autoimmune liver diseases.
Altered regulatory T cell function and abundance are central to autoimmune liver diseases, with significant differences observed between peripheral blood and liver tissue.
- Why it matters: Understanding Treg dysregulation is crucial because it underpins immune imbalance that damages hepatocytes and bile ducts, yet knowledge gaps remain about their precise roles across different AILDs.
- What they did: The review synthesizes human and preclinical data on Treg alterations in AILDs, examining their phenotypic diversity, tissue-specific changes, and the impact of the immune microenvironment and gut-liver axis.
- The result: Findings highlight the potential for Treg-targeted therapies to restore immune balance, but challenges in clinical translation necessitate further research into disease-specific Treg modulation strategies.