Circuit mechanisms of psychotic symptoms across disorders.

Disruptions in neurotransmitter systems across multiple scales cause circuit instability that underpins psychotic symptoms in diverse disorders.

• Why it matters: Understanding the shared neural mechanisms of psychosis can improve diagnosis and treatment across psychiatric and neurological conditions, addressing a major gap in current knowledge.
• What they did: The authors developed a multilevel, transdiagnostic framework integrating molecular, cellular, and circuit-level disturbances, supported by neuroimaging and computational approaches.
• The result: This model links neurochemical perturbations to circuit dysfunction and symptoms, paving the way for individualized, circuit-informed interventions for psychosis.