Decoding mitochondrial proteomes of diverse eukaryotes.

High-accuracy mitochondrial proteomes across diverse eukaryotes reveal extensive lineage-specific protein variation, expanding understanding beyond traditional animal and yeast models.

• Why it matters: Current knowledge of mitochondria is limited by a focus on a few model organisms, which overlooks the organelle's diversity across the eukaryotic tree of life, hindering comprehensive insights into its evolution and function.
• What they did: The MitoCarta Tree of Life Consortium employed experimental and computational methods to generate detailed mitochondrial proteomes from a wide range of eukaryotic species, creating a comparative framework.
• The result: This work provides a foundational resource for studying mitochondrial diversity, evolution, and disease, enabling broader and more accurate biological and medical research across eukaryotes.