Rewinding the gut clock: from chronodisruption to targeted therapies.
Disrupted circadian rhythms linked to metabolic and gastrointestinal diseases can be mitigated by targeted therapies that restore biological clock alignment.
- Why it matters: Modern lifestyle factors like shift work and irregular eating disturb internal clocks, increasing the risk of obesity, diabetes, and GI disorders, highlighting the need for effective interventions.
- What they did: Researchers review the hierarchical circadian system, focusing on gut clocks influenced by feeding cycles and microbial metabolites, and explore therapies such as time-restricted feeding, chronobiotics, and personalized chronotherapy.
- The result: Restoring circadian harmony through these strategies improves metabolic and GI health, offering promising avenues for preventing and treating diseases associated with chronodisruption.