Antigen prioritization and selection for vaccine design and development: A comprehensive pipeline.
A comprehensive, disease-agnostic pipeline for antigen prioritization enhances vaccine design by integrating biological and developability criteria, improving candidate selection.
- Why it matters: Effective vaccine development depends on selecting the right antigens, yet current approaches are fragmented across disciplines and disease areas, hindering progress.
- What they did: The pipeline employs a mechanism-driven decision framework, applying criteria such as biological essentiality, conservation, and safety across diverse indications, including infectious diseases, cancers, and autoimmune disorders.
- The result: This unified approach enables more rational antigen selection, supports the development of viable vaccine candidates, and leverages AI and digital modeling to predict immune escape and accelerate preparedness.