A single-dose topical therapy cures scabies in a human-relevant porcine model.

A single 4-hour topical therapy eradicates all mites and eggs in a human-relevant porcine model of severe scabies, outperforming standard oral ivermectin.

• Why it matters: Current treatments for scabies are limited by the need for multiple doses, lack of ovicidal activity, and rising resistance, hindering effective disease control.
• What they did: Researchers developed a topical combination of abametapir and flavesone, targeting multiple parasite stages through distinct mechanisms, and tested it in a porcine model of severe scabies.
• The result: The therapy achieved complete eradication of mites and eggs, reduced pruritus, and demonstrated pharmacokinetics supporting single-dose efficacy, offering a simplified, resistance-resilient treatment option.