SingPro 2.0: a proteomics-centric knowledge base for single-cell multimodal profiling.

SingPro 2.0 is the first comprehensive proteomics-centric database for single-cell multimodal data, covering 814 studies and 81.5 million cells across diverse tissues and diseases.

• Why it matters: Understanding cellular heterogeneity and disease mechanisms requires integrated datasets that include protein information, which are scarce in existing databases, limiting research progress.
• What they did: The updated SingPro systematically curates data from multiple studies, encompassing five omics modalities and twelve experimental technologies, enabling joint visualization and analysis of proteins with other molecular features.
• The result: This resource facilitates advanced cellular and disease research by providing accessible, multi-dimensional single-cell data, supporting the construction of detailed cell atlases and mechanistic insights.