Cell atlas of the developing human meninges reveals a dura-like nature of meningiomas.

Meningiomas originate from dura-lineage cells, as shown by their transcriptional similarity to fetal dura tissue, highlighting a dura-like nature of these tumors.

• Why it matters: Understanding the cellular origin of meningiomas is crucial for developing targeted therapies, especially for resistant cases, but current knowledge is limited and lacks molecular evidence.
• What they did: Researchers created a detailed single-cell and spatial transcriptomic atlas of human fetal meninges from weeks 5-13, revealing the development of meningeal layers and dura-specific gene expression.
• The result: Findings suggest meningiomas may arise from dura-lineage cells, providing new insights into their biology and potential avenues for targeted treatment strategies.