DiCE-Ex: a web server for network-based differential-centrality gene exploration.

DiCE-Ex uncovers condition-specific regulatory genes by analyzing network centrality shifts, identifying key mediators even without large expression changes.

• Why it matters: Understanding disease drivers requires detecting dynamic network rewiring that traditional methods often miss, limiting insights into condition-dependent regulation and potential therapeutic targets.
• What they did: The web server integrates gene expression data with protein-protein interaction networks to construct condition-specific weighted networks and evaluates multiple centrality measures to identify rewired genes.
• The result: DiCE-Ex successfully recovers known disease modulators and reveals overlooked nonhub regulators, enabling more accurate mechanistic insights and candidate gene prioritization for therapy development.