circRNADisease v3.0: an updated resource for high-quality, experimentally supported circRNA-disease associations.
circRNADisease v3.0 expands to include over 15,390 curated circRNA-disease entries, doubling data volume and enhancing evidence support for understanding circRNA roles in diseases.
- Why it matters: Understanding circRNA-disease associations is crucial for uncovering disease mechanisms and developing biomarkers or therapies, yet comprehensive, high-quality data has been limited.
- What they did: The team integrated extensive experimental evidence, genomic data, and new modules—Circ2CNV and Circ2Celltype—covering genomic variations and cell-type-specific information across 66 species, involving nearly 9,168 circRNAs.
- The result: This enriched database offers a detailed, confidence-scored resource that links circRNAs to diseases, genomic alterations, and cellular contexts, facilitating advanced research and therapeutic development.