Integrated proteomic and metabolomic analyses define the molecular architecture of acute mountain sickness.

Integrated proteomic and metabolomic analyses reveal a distinct molecular signature of acute mountain sickness with 3,137 proteins and 4,104 metabolites differentiating affected individuals.

• Why it matters: Understanding the systemic molecular features of AMS is crucial for developing targeted diagnostics and therapies for hypoxia-related disorders, yet these features remain poorly characterized.
• What they did: Researchers performed comprehensive plasma profiling on 81 healthy Han Chinese men after high-altitude exposure, employing differential analysis, WGCNA, tissue mapping, regulatory network reconstruction, and machine learning to identify biomarkers and potential drug targets.
• The result: Findings highlight coordinated thrombo-inflammatory responses, metabolic reprogramming, and liver-centered proteomic architecture, with key regulators like NOTCH1 and GSTA1, enabling improved diagnosis and therapeutic strategies for hypoxia-induced conditions.