Diversity of ITS genotypes in Trichophyton mentagrophytes species complex isolates causing tinea corporis and tinea capitis: a multicenter study in France.
T. indotineae and T. mentagrophytes ITS genotype VII together account for 39.1% of T. mentagrophytes complex isolates in France, highlighting emerging public health concerns.
- Why it matters: Understanding the diversity and distribution of ITS genotypes is crucial for diagnosing and managing dermatophyte infections, especially as new genotypes emerge with potential treatment resistance.
- What they did: The study sequenced ITS regions from 92 clinical isolates from French skin and scalp samples, identifying five genotypes within T. mentagrophytes sensu stricto and analyzing their patient demographics and resistance markers.
- The result: Findings show T. indotineae and genotype VII are prevalent, with genotype VII isolated exclusively from adult men, and T. indotineae harboring mutations linked to terbinafine resistance, informing targeted treatment strategies.