Clinical profile and outcomes of persistent candidemia: A matched case-control study.

Persistent candidemia occurs in 1 out of 3 cases and is linked to higher mortality and longer hospital stays in hospitalized patients.

• Why it matters: Understanding factors that contribute to persistent bloodstream infections is crucial for improving treatment outcomes and reducing mortality in invasive fungal infections.
• What they did: A retrospective, matched case-control study analyzed 47 cases of persistent candidemia and 94 controls across three U.S. tertiary centers, examining clinical features and outcomes.
• The result: Presence of a central venous catheter and ICU admission were strongly associated with persistence, which led to increased mortality (40.4%) and extended hospitalization, highlighting targets for intervention.