Genome-wide cis-expression Quantitative Trait Loci (eQTL) and transcriptomic signals reveal distinct molecular regulation across correlated feed efficiency traits.

Genomic and transcriptomic analyses identify 74 key genes and regulatory networks linked to feed efficiency traits in lambs, with 93 cis-eQTLs influencing gene expression.

• Why it matters: Understanding the molecular basis of feed efficiency is crucial for improving livestock productivity and sustainability, yet the genetic mechanisms remain largely unknown.
• What they did: The study combined differential gene expression, co-expression network analysis, and cis-eQTL mapping on blood samples from lambs, identifying genes and regulatory variants associated with traits like DMI, ADG, and RFI.
• The result: Findings reveal specific genes and pathways that can be targeted for breeding strategies to enhance feed efficiency, enabling more sustainable livestock production.