Stretching the secretory pathway: Mechanical control of Golgi export.

Mechanical signals from cell spreading directly influence Golgi function, modulating its secretory output in a feedback loop that supports cell spreading.

• Why it matters: Understanding how mechanical forces affect intracellular organelles like the Golgi is crucial for revealing how cells adapt their functions during movement and growth, filling a key knowledge gap in cell mechanobiology.
• What they did: Naidu et al. examined the Golgi’s response to cell-spreading forces, demonstrating that mechanical cues can regulate Golgi activity and secretion through a feedback mechanism.
• The result: This work shows that mechanical signals extend into the secretory pathway, enabling cells to dynamically adjust secretion in response to physical forces, which may influence tissue development and repair.