TIME in motion: How response takes shape.

Immune-state remodeling during therapy predicts outcomes better than baseline tumor microenvironment composition across cancers.

• Why it matters: Understanding dynamic immune responses is crucial for improving immunotherapy effectiveness, as current biomarkers mainly focus on static tumor features.
• What they did: Lin et al. created a longitudinal pan-cancer single-cell atlas, analyzing immune changes over time during treatment to assess immune remodeling.
• The result: They found that the direction of immune-state changes provides more predictive insight into therapy response than initial immune profiles, guiding better biomarker development.