Constitutive transcriptomic reprogramming underlies differential resistance of Flammulina velutipes to Pseudomonas tolaasii.

Constitutive gene expression differences underpin resistance to Pseudomonas tolaasii in Flammulina velutipes, with 634 genes up-regulated in resistant strains.

• Why it matters: Understanding the molecular basis of strain-dependent resistance is crucial for developing disease-resistant mushroom cultivars and improving crop resilience.
• What they did: The study compared resistant and susceptible strains using dual-culture assays, SEM, and transcriptome profiling, revealing that resistance correlates with pre-existing gene expression patterns.
• The result: Findings suggest resistance relies on a constitutive defense state involving redox regulation and cell wall integrity, enabling targeted breeding for resilient F. velutipes cultivars.