Kinetics of anti-Aspergillus spp. IgG antibodies in COVID-19-associated pulmonary aspergillosis.

Anti-Aspergillus spp. IgG antibodies seroconvert in 70% of COVID-19-associated pulmonary aspergillosis patients, typically around 8 days after diagnosis in ICU settings.

• Why it matters: Diagnosing CAPA is challenging due to non-specific symptoms and radiological findings, creating a need for reliable biomarkers to improve detection and management.
• What they did: A retrospective study analyzed 43 ICU COVID-19 patients with CAPA, measuring AspAb levels and observing seroconversion patterns, with 70% showing positive antibody responses.
• The result: Findings suggest AspAb testing could aid CAPA diagnosis, as most seroconverted within days of diagnosis, paving the way for larger studies to validate antibody kinetics in non-neutropenic ICU patients.