A new core-genome MLST approach for Chlamydia trachomatis genomic surveillance and research.
- Open access
A new core-genome MLST system for Chlamydia trachomatis enables standardized global genomic surveillance with 846 loci, accurately reflecting major lineages.
- Why it matters: Effective classification and tracking of C. trachomatis strains are limited by technical challenges and lack of standardized tools, hindering global public health efforts.
- What they did: Researchers curated a diverse genome dataset of 1230 samples from 26 countries and developed a cgMLST framework validated for high typeability and congruence with existing methods.
- The result: The cgMLST schema accurately recapitulates major lineages, reveals intra-lineage diversity, and links genetic traits to phenotypes, facilitating harmonized, worldwide strain tracking and functional insights.