A multiancestry polygenic risk score for Alzheimer's disease is associated with cognitive decline and neuropathological hallmarks in diverse populations.

A multiancestry polygenic risk score for Alzheimer's disease predicts cognitive decline and neuropathological features across diverse populations, with odds ratios up to 1.65.

• Why it matters: Current polygenic risk scores often perform poorly across different ancestries, limiting their usefulness in diverse populations and hindering equitable risk assessment and early intervention strategies.
• What they did: Researchers developed an APOE-independent AD PRS using genome-wide association data applied to European, African American, Caribbean Hispanic, and East Asian cohorts, then validated it in multiple independent datasets.
• The result: The PRS was significantly associated with AD and related cognitive and neuropathological measures in all groups, supporting its role in improving risk stratification and understanding disease mechanisms across diverse populations.