Galanin impairs tumor immunity in glioblastoma by promoting infiltration and ferroptosis resistance of myeloid-derived suppressor cells.

Galanin promotes immunosuppression and ferroptosis resistance in glioblastoma by enhancing myeloid-derived suppressor cell infiltration, leading to immunotherapy resistance in mouse models.

• Why it matters: Glioblastoma’s resistance to immunotherapy limits treatment options and worsens patient outcomes. Understanding mechanisms of immune evasion is crucial for developing effective therapies.
• What they did: The study examined how galanin secreted by glioblastoma cells interacts with GALR3 on mMDSCs, activating a signaling pathway that increases their infiltration and ferroptosis resistance, using molecular and animal models.
• The result: Targeting GALR3 and inducing ferroptosis reduced tumor growth and, when combined with anti-PD1 therapy, resulted in complete tumor regression in about 60% of mice, suggesting a promising therapeutic approach.