Circadian control of circulating tumour-derived extracellular vesicle secretion affects targeted therapy efficacy.
Circadian oscillations in circulating tumour-derived extracellular vesicle abundance and function influence targeted therapy outcomes in mouse tumour models.
- Why it matters: Understanding the circadian regulation of ctEVs is crucial because these vesicles promote tumour progression and may impact treatment effectiveness, yet their dynamics are poorly characterized.
- What they did: The study developed ctEV-CLOCK, a method combining metabolic glycoengineering and click tagging to isolate nascent ctEVs every 12 hours, revealing circadian patterns in their levels and protein profiles.
- The result: Synchronizing targeted therapy with peak ctEV protein abundance significantly improves treatment efficacy, highlighting the potential for circadian-based cancer chronotherapy strategies.