Single-allele chromatin tracing reveals cytokine-dependent super-enhancer repositioning in CD4(+) T cells.

Cytokine-driven repositioning of a super-enhancer activates Ets1 and Fli1 in CD4(+) T cells, with the super-enhancer moving toward the locus center to promote gene expression.

• Why it matters: Understanding how cytokines influence gene regulation in T cells is crucial for deciphering immune responses and the development of immune-related diseases, yet the mechanisms remain unclear.
• What they did: The study used single-allele chromatin tracing and epigenomic profiling to analyze the Ets1-Fli1 locus in thymocytes and CD4(+) T cells, focusing on super-enhancer dynamics and chromatin interactions.
• The result: Cytokine-induced super-enhancer repositioning enhances gene activation and co-expression of Ets1 and Fli1, revealing a mechanism by which noncoding variants may contribute to immune disorders.