Haemodynamic control of zonated liver function via instructive vascular Wnt signalling.

Blood flow-induced haemodynamic stress regulates liver sinusoidal endothelial cell Wnt signalling, controlling metabolic zonation in the liver.

• Why it matters: Understanding how physical forces influence endothelial cell signalling is crucial for deciphering organ function regulation and addressing liver-related diseases.
• What they did: The study used single-cell RNA sequencing and spatial proteomics to map interactions between LSEC and hepatocytes in Wnt-deficient mice, revealing spatial enrichment of Wnt receptors and ligands.
• The result: Findings show that haemodynamic stress activates Wnt signalling in LSEC, enabling these cells to convert physical cues into instructive signals that coordinate liver zonation and function.