Metabolic inflammation, obesity, and cancer.

Obesity-induced metabolic and immune reprogramming in macrophages promotes cancer susceptibility and progression across tissues.

• Why it matters: Understanding how obesity alters immune cell function is crucial because it contributes to increased cancer risk and affects treatment responses, yet the mechanisms remain unclear.
• What they did: The review synthesizes current knowledge on macrophage adaptation to metabolic stress in adipose tissue and liver, and how obesity-driven myeloid reprogramming influences systemic immunity and tumor development.
• The result: Recognizing obesity-related immunometabolic dysfunction offers new insights into tissue-specific cancer responses and suggests potential avenues for targeted therapies and improved management strategies.