Clinical spectrum, clinical associations, and treatment outcomes of scedosporiosis in South India: A retrospective cohort study.

Scedosporiosis in South India predominantly causes osteomyelitis and sinusitis, with a high mortality rate in severe cases, differing from patterns seen elsewhere.

• Why it matters: Understanding the clinical presentation of scedosporiosis is crucial for timely diagnosis and management, especially since it often mimics bacterial infections and resists standard antifungal treatments.
• What they did: The study reviewed 18 culture-confirmed cases from 2016 to 2024, focusing on clinical features, microbiology, and outcomes, highlighting osteomyelitis and sinusitis as common presentations.
• The result: Findings suggest that early suspicion and targeted antifungal therapy, mainly voriconazole, along with surgical intervention, can improve outcomes in this distinct disease pattern.