Misfirin' pyrin.

CDC42 binds to pyrin B30.2 domain, revealing a new mechanism regulating pyrin inflammasome activation.

• Why it matters: Understanding how pyrin inflammasome activity is controlled is crucial for insights into inflammatory diseases, yet this regulatory pathway was previously unknown.
• What they did: The study involved three separate investigations that demonstrated CDC42 as a binding partner of the pyrin B30.2 domain, uncovering a novel interaction.
• The result: This discovery provides a new target for modulating inflammasome activity, potentially leading to improved treatments for inflammatory conditions.