Lactobacillus gasseri postbiotics ameliorate age-related decline in endometrial receptivity.

Lactobacillus gasseri postbiotics improve endometrial receptivity and implantation in aged models, counteracting age-related fertility decline with a 40% enhancement in mice.

• Why it matters: Age-related changes in the uterine microbiome, especially the loss of beneficial Lactobacillus species, impair endometrial function and reduce fertility in women of advanced reproductive age, creating a need for targeted interventions.
• What they did: Researchers analyzed a human cohort to identify microbiome shifts and screened reproductive tract isolates, focusing on L. gasseri, which was tested in cells and aged mice for its antioxidant, anti-inflammatory, and adhesion properties, including its exopolysaccharides (EPSs).
• The result: L. gasseri and its EPSs attenuated endometrial aging markers, improved implantation rates, and modulated Hippo-YAP signaling, suggesting that restoring Lactobacillus and applying EPSs could enhance fertility outcomes in older women.