Mechanical forces stimulate Golgi export.

Extracellular mechanical signals enhance Golgi export, increasing secretory activity by up to 50% in adherent cells under mechanical stress.

• Why it matters: Understanding how cells adapt their internal organelles to mechanical forces is crucial for revealing mechanisms behind tissue development, repair, and disease progression, yet remains largely unexplored.
• What they did: The study applied mechanical challenges such as cell spreading, substrate stiffness changes, and strain to cells, then measured Golgi-to-surface carrier formation and exocytosis, identifying key molecular pathways involved.
• The result: Mechanical stimulation boosts Golgi export through pathways involving microtubule acetylation, diacylglycerol, and protein kinase D, and disrupting this process impairs cell spreading, highlighting a mechanotransduction axis critical for cellular adaptation.