Additive value of polygenic risk and family history for coronary heart disease risk stratification in two diverse US cohorts.

Polygenic risk scores and family history together improve coronary heart disease prediction across diverse US populations, increasing true-positive detection by nearly 19%.

• Why it matters: Accurate CHD risk stratification is essential for targeted prevention, but the additive value of genetic and familial factors across different racial and ethnic groups remains unclear.
• What they did: The study analyzed data from two large cohorts, eMERGE IV and All of Us, using statistical models to assess how polygenic risk scores and family history independently and jointly predict CHD, and evaluated their impact on existing risk algorithms.
• The result: Adding polygenic risk scores and family history to clinical models enhanced prediction accuracy and reclassification, with consistent benefits across White, Black, and Latino groups, supporting their integration into risk assessment tools.