Faster inference of complex demographic models from large allele frequency spectra.

Momi3 accelerates complex demographic model inference from large allele frequency spectra by up to an unspecified speedup, enabling analysis of multiple populations and samples.

• Why it matters: Understanding demographic history from genetic data is computationally challenging with increasing data complexity, limiting insights into population dynamics.
• What they did: The authors developed momi3, a JAX-based Python tool supporting continuous migration, GPU execution, automatic differentiation, and genealogical pruning to improve inference efficiency.
• The result: Momi3's enhancements significantly reduce computation time, facilitating more detailed demographic analyses and advancing population genetics research.