Direct and indirect regulation of fetal globin transcript by the RNA-binding protein IGF2BP1.
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IGF2BP1 directly binds HBG1/2 transcripts and activates HIC2, revealing a dual mechanism regulating fetal hemoglobin expression.
- Why it matters: Understanding hemoglobin switching is crucial for developing therapies for hemoglobinopathies, but the molecular regulation remains incompletely understood, especially regarding RBPs.
- What they did: The study used binding assays and transcript analysis to show IGF2BP1 interacts with HIC2 and HBG1/2 transcripts, promoting their translation through m6A-modified coding sequences.
- The result: This discovery clarifies how IGF2BP1 influences fetal hemoglobin, offering new insights into hemoglobin regulation and potential targets for therapeutic intervention.