β-Glucan and Inulin Estimated Intake Are Associated With Reduced Risk of Crohn's Disease, Improved Gut Barrier and Systemic Inflammation Markers, and Multi-Omic Signatures in a High-Risk Cohort.

Higher intake of β-glucan and inulin is linked to a 30% reduction in Crohn's disease risk in a high-risk cohort over 8.5 years.

• Why it matters: Crohn's disease has an unclear cause, but dietary fiber may influence its development; understanding this link could lead to preventive strategies.
• What they did: The study analyzed dietary fiber intake, gut microbiota, and inflammation markers in 3,314 first-degree relatives of Crohn's patients, using food questionnaires, biological samples, and multivariable models.
• The result: Increased β-glucan and inulin consumption correlated with improved gut barrier function, reduced systemic inflammation, and lower Crohn's disease risk, especially in individuals with specific microbial profiles.