Blood · 20 Aug 2026 · Journal Article

No overall increased risk of death in individuals with sickle cell trait: a study of 467 779 general population adults.

Warny, Glenthøj + more

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Reactivation of the embryonic ζ-globin gene ameliorates severe forms of α-thalassemia.
Nature Genetics · 1 Oct 2026 · Journal Article
Reactivating the silenced embryonic ζ-globin gene restores therapeutic hemoglobin levels in severe α-thalassemia models, including lethal forms like Hb Bart's hydrops fetalis.
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Human genetics implicates a BACH2-NRF2 axis in fetal haemoglobin activation.
Nature · 30 Sept 2026 · Journal Article
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The CYB5R3 T117S missense variant is associated with attenuated riociguat efficacy in sickle cell disease.
Blood · 24 Sept 2026 · Journal Article
The CYB5R3 T117S variant reduces riociguat efficacy by impairing nitric oxide signaling in sickle cell disease patients.
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