bioRxiv · 25 Sept 2026 · Preprint · Open access

Articular calcified cartilage microarchitecture has a predictive role in abnormal osteochondral strain distributions in murine age-related osteoarthritis

Evans, Sharma + 9 more

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The gene-regulatory evolution of the human skeleton.
Nature · 23 Sept 2026 · Journal Article
Gene-regulatory changes in over 15,000 loci drove extensive remodeling of the human skeletal extracellular matrix, including a three-to-fourfold reduction in joint GAG content.
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Targeting pro-senescent PTGS2(+) macrophages alleviates chondrocyte senescence and osteoarthritis progression.
Cell Reports · 22 Sept 2026 · Journal Article
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Influence of homozygosity on genomic structural variation analyses for predicting ACL rupture risk in the Labrador Retriever and Rottweiler.
Frontiers in Genetics · 3 Sept 2026 · Journal Article
Increased homozygosity significantly raises ACL rupture risk in Rottweilers but not in Labrador Retrievers, highlighting breed-specific genetic influences.
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