bioRxiv · 10 Aug 2026 · Preprint · Open access

Chemoselective Bioconjugation Reveals Norepinephrinylation (NEylation) as a Widespread Post-Translational Modification in Cells

Lin, Ma + 13 more

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Therapeutic targeting of IL-17A-driven PTGS2/NLRP3 inflammasome activation in juvenile myelomonocytic leukemia.
Blood · 17 Sept 2026 · Journal Article
In PTPN11-mutant juvenile myelomonocytic leukemia, dual NLRP3 and PTGS2 inhibition combined with MEK blockade significantly prolongs survival and reduces leukemic burden in models.
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PADI-dependent mitochondrial adaptation drives resistance to KRAS inhibitors.
Cell Reports · 17 Sept 2026 · Journal Article
PADI1 and PADI3 promote resistance to KRAS inhibitors by sustaining mitochondrial adaptation in KRAS-driven tumors.
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Integrative pan-cancer analysis suggests ISG15-linked immune and phosphoproteomic divergence between KIRC and KICH
bioRxiv · 14 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2024.10.18.619140
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