Ketone ester supplementation reduces age-associated B cell activation in aged mice without impairing antibody responses

Ketone ester supplementation reduces activation of age-associated B cells in aged mice by 50% without impairing antibody responses.

• Why it matters: Aging weakens immune responses, increasing infection risk and autoimmunity, with no current interventions to reverse or slow immune aging.
• What they did: Researchers fed 19-month-old mice a ketone ester diet for 15 weeks, analyzing B cell activation, antibody production, and mTOR signaling pathways.
• The result: The diet lowered B cell activation and glucose dependence while preserving antibody responses, suggesting ketone esters modulate immune aging and could improve immune health.