bioRxiv · 28 Aug 2026 · Preprint · Open access

Sphingosine 1-phosphate receptor-1 signaling enhances neutrophil survival while suppressing inflammation and bacterial host defense functions

Lin, Seno + 13 more

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Lysosomal multi-omics reveals altered sphingolipid catabolism associated with lysosomal dysfunction in the aging brain.
Cell Reports · 1 Oct 2026 · Journal Article
Lysosomal lipid and protein changes in the aging brain show increased myelin components and disrupted sphingolipid breakdown, especially in microglia, indicating dysfunction.
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Dissipation of lysosome pH impairs formation and collapses existing LPS-induced lysosome tubules in macrophages
bioRxiv · 22 Sept 2026 · Preprint
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https://jclub.com.au/a/10.1101/2025.09.25.677195
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Processing of lysophosphatidylcholines by ExoU secreted by P. aeruginosa leads to inflammasome activation and cell death.
Cell Reports · 22 Sept 2026 · Journal Article
ExoU secreted by P. aeruginosa increases lysophosphatidylcholine levels, activating inflammasomes and causing cell death, with significant implications for cystic fibrosis infections.
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https://jclub.com.au/a/42771524
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