bioRxiv · 25 Sept 2026 · Preprint · Open access

Disruption of NUAK2-Mediated RNA Splicing by Trilaciclib Reveals a Therapeutic Vulnerability in AR-Indifferent Prostate Cancer

Mehraj, Maimekov + 16 more

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PROTEUS May Mean New SOC for Some Prostate Cancers.
Cancer Discovery · 9 June 2026 · News
Adding apalutamide to androgen deprivation therapy improves 5-year metastasis-free survival to 78.2% in high-risk localized prostate cancer patients.
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Perioperative Apalutamide in High-Risk Localized Prostate Cancer.
New England Journal of Medicine · 6 Aug 2026 · Randomized Controlled Trial
Perioperative ADT plus apalutamide improves pathological response and metastasis-free survival in high-risk prostate cancer patients undergoing prostatectomy, with 8.9% achieving complete response.
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