Lineage and renewal dynamics of sebaceous glands govern skin barrier integrity in mice.

Murine sebaceous glands display dynamic heterogeneity and distinct regenerative responses, with Krt15+ cells giving rise to diverse gland types via divergent pathways.

• Why it matters: Understanding SG cell biology and lineage is crucial for maintaining skin barrier integrity and addressing skin disorders, yet these processes are poorly characterized in vivo.
• What they did: Using bulk isolation, molecular profiling, SG-specific mouse models, and lineage tracing with SG-Chaser mice, the study identified SG heterogeneity, stem cell behaviors, and differentiation trajectories involving Krt15+ cells.
• The result: Findings reveal that modulating Pparγ activity can effectively regulate sebocyte homeostasis, offering potential strategies to preserve skin barrier function and treat related skin conditions.