Right size, right time: The Hippo-IGF2 axis calibrates liver growth and regeneration.

Hippo signaling controls Igf2 expression to regulate liver growth and regeneration, highlighting a key mechanism for organ size calibration in postnatal stages.

• Why it matters: Understanding how organ size is precisely regulated after birth is crucial for developing therapies for liver diseases and regenerative medicine, yet the molecular links remain unclear.
• What they did: The study examined the connection between Hippo signaling and Igf2 expression, demonstrating that Hippo pathway activity influences Igf2 levels during liver growth and regeneration in postnatal mice.
• The result: Findings reveal that Hippo-controlled Igf2 expression is essential for proper liver size and regenerative capacity, providing insights into organ size regulation and potential targets for regenerative therapies.