Chemo-metallo nanodrivers for spatiotemporally controlled in situ vaccination.
Zinc-based chemo-metallo nanodrivers induce PANoptosis and enhance immune response, achieving effective in situ cancer vaccination in mouse models of gastric cancer.
- Why it matters: Overcoming limited antigen release and immune resistance remains a challenge for in situ cancer vaccines, hindering their therapeutic potential. Understanding how metal ions like Zn2+ can modulate immune pathways offers new avenues for improving immunotherapy.
- What they did: A nanodriver was engineered using zinc-aluminum layered double hydroxides to co-deliver cisplatin and indocyanine green, enabling controlled release upon photoactivation and disrupting tumor zinc homeostasis to activate immune pathways.
- The result: The nanodriver triggered a STING-PANoptosis cascade, boosting dendritic cell maturation, cytokine secretion, and establishing durable immune memory, thus advancing precise gastric cancer immunotherapy.