Predicting and finding geroprotective compounds through modulating conserved longevity-associated aging modules.

Modulating conserved longevity-associated gene modules enables prediction and validation of 10 geroprotective compounds that extend lifespan in C. elegans, including 7 novel candidates.

• Why it matters: Current tools lack the ability to predict how interventions impact aging through gene expression changes, limiting the discovery of effective geroprotectors and understanding of aging mechanisms.
• What they did: The study deconstructed the aging transcriptome into coexpression modules, identified those linked to lifespan extension in C. elegans, and validated compounds that modulate these modules through lifespan assays and RNA sequencing.
• The result: The identified compounds significantly extended lifespan in C. elegans, and conserved modules in mice correlated with frailty, providing a framework for discovering geroprotectors targeting aging-related transcriptomic changes.