Intratumoral therapeutic dust for chemo-photodynamic combination treatment.

Injectable, lead-free TheraDust microdevice achieves over 97% tumor volume reduction in breast cancer models through wireless chemo-photodynamic therapy.

• Why it matters: Effective intratumoral treatment for deep-seated tumors is limited by device miniaturization and toxicity concerns, hindering clinical translation of wireless ultrasound therapies.
• What they did: A submillimeter, lead-free TheraDust device was developed using tin-doped barium titanate ceramic, integrated with an ultrasound-responsive drug hydrogel, enabling precise, programmable therapy.
• The result: The device significantly suppressed tumor growth after five sessions, enabling minimally invasive retrieval and demonstrating potential for versatile, wirelessly controlled treatments of deep tissues.